The MoSBurn project aims to model the Burnout (considering the three dimensions: exhaustion, cynicism and effectiveness) of college students based on a quantitative study that includes questionnaires with internationally validated scales. Burnout is a state of emotional, mental and physical exhaustion caused by excessive and prolonged stress (distress), which has a detrimental effect on students' academic performance and can ultimately lead to dropout. Recently, this problem seems to have increased due to the pandemic of COVID-19, which is a major concern for universities. By applying the Structural Equation Modeling, it is expected to estimate a model that allows identifying which (in)direct effects are statistically significant regarding burnout of college students, considering optimism and distress as potential predictors. Understanding the results may help suggest some intervention to improve student performance and help universities in their mission to provide well-being and quality education to their students.